These higher research doses established safety margins while demonstrating therapeutic efficacy
GSH deficiency induced in cultured hepatocytes caused an increase in oxidative stress and alterations in VD regulatory genes
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Other research applications Preclinical studies have evaluated ARA-290 in an impressive range of models: diet-induced insulin resistance, diabetic retinopathy, diabetic autonomic neuropathy, myocardial infarction, chronic heart failure, burns, traumatic brain injury, and shock-induced multi-organ failure
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