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In CRPC, AR signaling upregulates inhibitory immune checkpoints (e.g., B7-H3) and proinflammatory cytokines (e.g., IL-6, TNF-), which recruit immunosuppressive cells and suppress T-cell function
Mol biomedicine
Mushrooms: Natural factory of anti-oxidant, anti- inflammatory, analgesic and nutrition
Similar to mammalian EVs, plants utilize the conserved MVBintraluminal vesicle (ILV) pathway as a core mechanism for vesicle secretion [49]
Second, the mechanistic stratification across nitric-oxide, cytoskeletal, and copper-mediated ECM pathways gives research designs clean tool separation
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