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The combination of both effects is the pharmacological rationale of the stack
In trauma and hemorrhagic shock models, elevated circulating mtDAMPs levels correlate with injury severity and drive a SIRS that clinically mimics sepsisa phenomenon termed sterile sepsis or autosepsis. Notably, experimental administration of purified mtDAMPs is sufficient to recapitulate neutrophil-mediated organ injury and hemodynamic collapse, establishing a direct causal link between IR-induced mitochondrial disruption and SIRS-like systemic inflammation ( The IR-mtDAMPs axis creates a feed-forward amplification loop: IR injury causes mitochondrial damage and mtDAMPs release
AHK-Cu is a copper-binding tripeptide (alanyl-histidyl-lysine complexed with copper) used as a research reference material
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Iffland K, Grotenhermen F
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