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Early intervention with B12 injections can help prevent or reduce these symptoms, improving quality of life

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In fact, it has been demonstrated that caspase-3 leads to ZO-1 and claudin-5 disruption in endothelial cells even in the absence of apoptotic death, indicating a non-apoptotic role in barrier regulation (Zehendner et al., 2011

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It is possible that it could increase, decrease, or be unchanged

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