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Based on the Phase 2 dose-response data, the Phase 3 program focuses on the doses that showed the strongest efficacy: the 8mg and 12mg maintenance doses, with a gradual titration schedule to manage gastrointestinal side effects during the early weeks of treatment

Engagement of GPVI, PARs, and purinergic receptors activates PLC and increases intracellular Ca 2+ , part of which is taken up by mitochondria via the MCU

Presented for research literature review only Cao Y et al

To our knowledge, this was her first episode of a psychiatric crisis

Weight management injections have also demonstrated remarkable results

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