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Pregnancy and Oral Contraceptive Failure Triple agonists are presumed teratogenic based on rodent embryo-fetal toxicity data filed with phase 2 IND applications, consistent with the semaglutide label section 8.1
oral semaglutide therapy is not recommended during breastfeeding
To systematically evaluate the pathways driving this sensitivity, we performed continuous gene set enrichment analysis (GSEA) ranking all mapped genes by their Pearson correlation coefficient ( R ) between basal expression (log 2 (TPM + 1)) and the PRISM log 2 (fold de-enrichment) across the 470 matched cell lines (note that 5 cell lines were not listed on HPA and were therefore not included
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& Kang, W
Mild side effects such as nausea, digestive changes, or fatigue may occur, but they typically improve as the body adjusts
