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Clin Pharmacol Ther 111(1):272282 Ueda P, Wintzell V, Melbye M, Eliasson B, Sderling J, Gudbjrnsdottir S, Pasternak B (2023) Use of DPP4 inhibitors and GLP-1 receptor agonists and risk of intestinal obstruction: Scandinavian cohort study

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However, these agents are associated with increased thyroid cancer risk, and the packaging for these medications in the United States has a boxed warning stating that they are contraindicated in people with a personal or family history of medullary thyroid cancer and in patients with a diagnosis of multiple endocrine neoplasia syndrome type 2

This allows for higher dosing of the active ingredient, which helps maintain a healthy mucosal surface