da PHARMASTAR
When patients tolerate treatment, healthcare providers may increase the dose to 5 mg once weekly, followed by additional 2.5 mg increases every 4 weeks as needed and tolerated, up to a maximum maintenance dose of 15 mg once weekly
This choice was intended to avoid potential confounding associated with non-user comparisons and other active comparators that have been linked to a possible excess risk or decrease in risk of major adverse cardiovascular outcomes 27,47
This may lead to higher reductions in waist size for men than women when taking a GLP-1, he says
Additionally, as this work was conducted in a mouse model, caution should be exercised when extrapolating the findings to humans, since notable interspecies differences in anatomical distribution, thermogenic activity, and pharmacological responsiveness of BAT may affect translational relevance despite functional similarities
These medications may be appropriate in specific medical contexts, but they also carry real risks and tradeoffs
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