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On a molecular basis, the TRPA1 (Transient receptor potential ankyrin subtype 1) ion channels in nociceptors allow the release of calcitonin gene-related peptide (CGRP) from dural afferents upon activation, mediating neurogenic inflammation, and migraine behavioral picture in animal models (25)

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Calcium channel blockers (diltiazem, verapamil) that slow heart rate work through a different mechanism than retatrutide

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Shin D, Lee J, You JH, Kim D, Roh J-L

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