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These multiprotein complexes play a pivotal role in orchestrating the inflammatory response by enabling caspase-1dependent activation of the potent pro-inflammatory cytokines interleukin-1 (IL-1) and interleukin-18 (IL-18) upon detection of cellular danger signals (233)

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Some people find caffeine on an empty stomach sits poorly, so having coffee with or after breakfast rather than first thing may work better