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Whats actually in my fridge on GLP-1 No gatekeeping over here this is whats been helping me stay consistent and lose 20 pounds in 4 weeks
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Semaglutides introduction of a fatty acid side chain at position 26 Lys allows reversible binding to plasma albumin and reduces renal clearance, and substitution of amino acids at positions 8 and 34 with Aib and Arg avoids its degradation by DPP-4 and prevents fatty acid binding at the wrong site, resulting in a once-weekly dosing (Lau et al., 2015
Nat Med (2022) 28:5918
Throughout, the reduction processes for all solutions were kept at a temperature of 60C in the dark place to avoid any photochemical reactions
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