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CD4 + T cells co-cultured with activated LECs reduced their production of activation cytokines (IL-2, IL-10, IFN-g), confirming the role of LECs in the suppression of CD4 + T cells in TDLNs (199)

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364,365 PDPN is associated with increased thalamic vascularity and functional reorganization of the primary somatosensory cortex

To reduce the effector functions mediated by the Fc fragment, researchers converted the antibody subtype to a non-glycosylated mouse IgG1 subtype by introducing an N297 to G mutation to achieve deglycosylation

PMID 13032078

Mechanistic insight provided by glutaredoxin within a fusion to redox-sensitive yellow fluorescent protein