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The Company subsequently retained Joele Frank, Wilkinson Brimmer Katcher
used TCGA, The University of Alabama at Birmingham Cancer (UALCAN), KaplanMeier plotter, The Breast cancer Gene-Expression Miner v4.7 (bc-GenExMiner v4.7), cBioPortal, STRING, Enrichr, MethSurv, and Tumor IMmune Estimation Resource (TIMER) for bioinformatics analysis, to find that high levels of CCL 4/5/14/19/21/22 were associated with better overall survival (OS) and recurrence-free survival (RFS), while elevated expression of CCL 24 was associated with shorter OS in BC patients
It is believed that effects on the TGF-1 pathway and consequently on proliferation, myofibroblast differentiation and collagen deposition are involved (104)
doi: 10.1097/QAD.0b013e32830a5058
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