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For peripheral vascular disease, where reduced blood flow to the extremities causes pain and tissue damage, this collateral activation mechanism could theoretically provide meaningful benefit
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As Professor Edison noted, this means a negative trial result may indicate lack of drug access to the brain, rather than failure of the concept itself. Dr Ivan Koychev, Clinical Associate Professor in Neuropsychiatry at Imperial, pointed out potential future developments: This is a recurring theme in Alzheimers disease therapeutics
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