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This stepwise dosing and adjustment schedule is essential because higher-than-prescribed doses can trigger stronger reactions, while too little may not deliver the intended benefits
Capsaicin sensitivity was not significantly affected by acute treatment with 100 nM oxyntomodulin (15 neurons), exendin-4 (7 neurons), or GLP-1 (11 neurons), compared to controls (12 neurons), using calcium imaging (Fig 9F), but responses to 100 M ATP were significantly enhanced in the presence of 3.5 nM exendin-4 (*p = 0.02, 4 neurons) (Fig 10)
Keep an eye on: Aim for two sessions per week focusing on major muscle groups
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