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or ii) aged 60 years with at least one CV risk factor (persistent microalbuminuria or proteinuria, hypertension with left ventricular hypertrophy, left ventricular systolic or diastolic dysfunction, or an anklebrachial index 7% in PIONEER 6 and different restrictions on permitted background glucose-lowering medication

The procedure takes approximately 30 minutes, and there is sometimes mild redness and burning (similar to a sunburn) for 1-2 hours after the treatment