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This produces soluble factors which can induce demyelination or neurodegeneration either directly or indirectly through microglia activation (Lassmann, 2018)

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Although the present study did not directly measure the activity or expression of these signaling molecules, these pathways were discussed based on previously published mechanistic studies demonstrating bromelains regulatory effects on NF-B, MAPK, MLCK, Nrf2, and Akt/FOXO signaling in various experimental models

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95% CI: 1.2, 4.4