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The pathogenic cascade is initiated by innate immune activation, characterized by KCs mobilization and neutrophil infiltration [8]

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During an asthma exacerbation and in the case of uncontrolled asthma, the airway environment becomes more acidic and oxidizing that leads to the release of NO from S-nitrosoglutathione (GSN), which leads to high levels of exhaled NO [2]

Mayo Clinic: "Vitamin B6" Cureus: "Anaphylactic Reaction to Cyanocobalamin: A Case Report" University of Michigan Health: "Biotin (Oral)" U.S