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This is significant for combination protocols because it suggests that adding cagrilintide to retatrutide may not dramatically increase the gastrointestinal burden, provided the titration is managed correctly

For context, the placebo group lost just 3%, while standalone semaglutide 2.4 mg produced 16.1% weight loss, and standalone cagrilintide achieved 11.5%

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Weight loss : In astudyof 175 participants with overweight or obesity, those taking semaglutide lost 5.9% of their body weight at 3 months and 10.9% at 6 months