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As NR increases the NAD + /NADH ratio, it could be related to an improvement of the oxidative capacity of the mitochondrial pathway and could be a therapeutic strategy of interest in those diseases that are associated with mitochondrial dysfunction and OS such as neurodegenerative diseases (Cant et al., 2012)

For instance, macrophages differentiate into different subtypes, participate in synovial inflammatory responses, and exacerbate cartilage damage by releasing inflammatory mediators (such as IL-1,TNF-) and proteases (such as MMPs,ADAMTs) ( At the same time, the differentiation of immune cells is influenced by the joint microenvironment

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\Cardiovascular Benefits: Reductions in systolic blood pressure and improvements in lipid profile

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