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Concurrently, reperfusion can induce vascular endothelial cell damage, promoting the upregulation of adhesion molecules such as von Willebrand factor (vWF), thereby enhancing leukocyte adhesion and transendothelial migration capacity

Success in developing these approaches could transform the clinical utility of peptide therapeutics by eliminating the need for injection

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For researchers concerned about cardiovascular risk, practical strategies to minimize TMAO production include supporting a healthy gut microbiome through prebiotic and probiotic use, monitoring TMAO levels if testing is available, and keeping total levocarnitine exposure within studied safety ranges

Perl A (2013) Oxidative stress in the pathology and treatment of systemic lupus erythematosus

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