3-AR knockout mice: In 3-AR gene knockout mice, the lipolysis effect of AOD 9604 was significantly weakened, confirming that its effect depends on the 3-AR signaling pathway
While this provides body composition benefits including fat loss and muscle growth, it also affects glucose metabolism (often elevating blood sugar), increases IGF-1 (with implications for cell proliferation), and costs significantly more than AOD-9604
[3] NNMT sits at an intersection of two important resource pools: it consumes SAM (the cells universal methyl donor) and it draws on nicotinamide that would otherwise feed the NAD salvage pathway
Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown
Typically, this means you must have a documented Vitamin B12 deficiency, which our providers can diagnose through appropriate blood tests
A., & Gennari, F