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Beyond proteasomal targeting, non-canonical ubiquitin modifications, including K63-linked polyubiquitination, regulate signaling, endocytosis, kinase activity, and DNA damage responses, while mono- and multi-ubiquitination influence chromatin dynamics, DNA repair, and subcellular localization (Fig

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5 Glucagon-like peptide-1 receptor agonists GLP-1R is targeted by GLP-1R agonists, which regulate diabetes and obesity