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This genetic knowledge highlights the multifactorial nature of vitiligo with a polygenic inheritance pattern, involving a complex interaction between immune system dysfunction and melanocyte dysfunction

PEA (palmitoylethanolamide) is a widely distributed lipid mediator that the body produces on demand

GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring tripeptide found in human plasma, saliva, and urine

Chronic mitochondrial inefficiency is an established source of continuous reactive oxygen species generation and can further compromise GSH synthesis and regeneration through effects on ATP production and the -glutamyl cycle [38]

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