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Other combinations of entero-pancreatic hormones including cagrisema (GLP-1/amylin RA) and the triple agonist retatrutide (GLP-1/GIP/glucagon RA) have also progressed to phase 3 trials as obesity treatments and early data suggests that may lead to even greater WL than tirzepatide

People with Certain Medications Long-term use of certain medications, like proton pump inhibitors, H2 receptor antagonists, or metformin, can interfere with B12 absorption

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In addition, high levels of B12 and NAD have been correlated with longer telomeres, specialized proteins at the ends of linear chromosomes

Patients who are particularly sensitive to GI side effects, who have a history of severe nausea with other medications, or who simply prefer a cautious approach may benefit from starting lower

Many patients find the investment worthwhile given the rapid symptom improvement and reliable results compared to oral options that may not deliver equivalent benefits