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Adherence to dietary and physical activity recommendations is often unmeasured, making it difficult to isolate medication effects from lifestyle factors

Judk P, Esposito S, Coppieters G, Van Eenoo P, Deventer K

"What makes it stand out is that it targets three hormone pathways simultaneously: GLP-1, GIP and glucagon, [which are] involved in hunger, fullness, blood sugar [regulation] and metabolism

Thats what people are trying to lose

Priority Review designation is possible given the magnitude of the trial results, which could shorten this timeline to 6 months

Days five through seven (the taper) As blood levels decline toward the end of the weekly cycle, some people notice a gradual return of appetite