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SIRT1 activation contributes to the suppression of NF-Bmediated inflammation, enhancement of autophagy, and improvement of muscle endurance, linking resveratrol directly to pathways relevant for sarcopenia ( Another critical layer of regulation involves microRNAs (miRNAs), which fine-tune gene expression post-transcriptionally

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We found that the inflammatory factors, Il-1, Il-6, Cxcl15 , and Tnf- , which are related to aging, were significantly decreased in the aging-related secretory phenotype (Figure 1B)

Addressing these challenges is essential for translating foundational insights into tangible clinical benefits, ultimately improving patient outcomes for both USP8-associated malignant and benign disorders