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Clinical trials demonstrate that most gastrointestinal symptoms are mild to moderate in severity and rarely lead to treatment discontinuation
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Common side effects of GLP-1 medications may include nausea, upset stomach, diarrhea, or constipation, especially when starting the treatment
However, the position of the cytoplasmic end of TM6 in the inactive state (either antagonist-bound or apo without G protein) structures is incompatible with the insertion of the C-terminus of GH5 (Fig
Secondly, we combined data from trials that varied in duration, baseline characteristics, and types of AOMs, which might result in heterogeneity to the meta-analysis, so we used a random-effects model for statistical analysis
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