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This novel anti-obesity and weight loss-promoting drug is the first twincretin, composed of GLP-1 receptor (GLP1-R) and GIP-receptor (GIP-R) agonists

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In cancer cells, mutations in succinate dehydrogenase subunit B (SDHB) cause susceptibility to familial pheochromocytoma 99 and familial paraganglioma 100 as well as gastrointestinal stromal tumors 101

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According to CMS, qualification requires a BMI of: BMI 35 with no additional clinical condition required , or BMI 30 with at least one of : heart failure, uncontrolled hypertension, or chronic kidney disease, or BMI 27 with at least one of : pre-diabetes, prior heart attack, prior stroke, or symptomatic peripheral artery disease