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DDR pathway activation phosphorylates and activates p53, which subsequently induces the expression of p21 23

11, e2101534

doi:10.1186/cc3742

In contrast, using targeted treatments for Fusobacterium , such as metronidazole or berberine, would be the recommended root cause approach

Feeling tired can sometimes be part of a detoxification response as the body redirects energy toward internal repair and "cleansing." If this persists, it may be a sign that your body needs more supportive cofactors like B vitamins or that you should adjust the timing of your dose to the evening

Bassareo V, Talani G, Frau R, Porru S, Rosas M, Kasture SB, et al