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You should not take retatrutide if you have: A personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 A history of pancreatitis Severe gastrointestinal disease, including gastroparesis Known hypersensitivity to any component of the drug You should use extreme caution and only proceed under close medical supervision if you have: Gallbladder disease or a history of gallstones Kidney disease, since dehydration from GI side effects can accelerate kidney damage Diabetic retinopathy, as rapid glucose changes can worsen it A history of eating disorders, since appetite suppression this powerful can interact badly with disordered eating patterns Retatrutide is also not approved for use in pregnancy
Yang F, Gao R, Luo X, Liu R, Xiong D
10.1038/s41392-021-00701-5 83 ZhangT.ChaboryE.BritanA.GrignardE.PitiotO.SaezF.et al (2008)
Low levels of B12 have been associated with peripheral neuropathy, cognitive impairment, and more rapid rate of disease progression in Parkinsons
An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol
Reducing oxidative stress and damage from free radicals
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