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Two details matter here
EQUIP showed modest BP and lipid improvement, but cardiovascular safety is uncertain [16]
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And prostaglandins do other things, too
This regulatory effect of DMF was identified through NRF2-dependent and independent mechanisms with NRF2 binding to ARE motifs and increasing DNA 5hmC of individual gene regulatory regions involved in the TSS pathway, cystine uptake, and GSH generation
While both agents have demonstrated promising results in clinical trials, several factors limit the generalisability of these findings and highlight the need for continued research and clinical evaluation
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