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Developed to investigate how the immune system responds to insulin, the Yalow and Berson method (figure 10) made it finally possible to accurately and rapidly measure tiny amounts of insulin and many other biologically interesting substances in a variety of body fluids, including blood, urine and saliva, as well as tissue extracts (Yalow, Berson)

This is particularly pertinent given the apparent increase in GSH in BPAD and reduction in unipolar depression, suggesting that the affective state may account for these differences

doi:10.23736/S2724-6507.20.03369-6 16

However, concerns have been raised about increased adverse psychiatric effectsspecifically, suicide

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This forced drug companies to go back to the FDA for a second approval, as every new use indication needs its own official stamp