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There are also cases of the higher range of 500mcg being used twice daily

Mayo Clinic: There's no solid proof that vitamin B-12 shots, also called injections, help you lose weight

The mechanism difference matters here

For subcutaneous B12 injections, a needle with a gauge of 25-27 and a length of 3/8 to 5/8 inch is commonly used

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Coat the injection site completely with ointment, following the instructions on the bottle or container as you go