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Single-nucleus RNA-sequencing shows opposing effects of GIPR agonism and antagonism in the hindbrain, with antagonism, but not agonism, mimicking GLP-1R signalling and with GIPR antagonism and GLP-1R agonism both regulating gene programmes implicated in synaptic plasticity
Not a mild one, but fairly significant
A correlation of XDH and GSS genes' expression and poor prognosis among breast cancer patients treated with tamoxifen was seen
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Supported by trials like EMPA-REG, LEADER, and CANVAS, though large dedicated combination trials are still ongoing.
Another standout feature is its versatility
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