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A C20 fatty diacid acyl chain attached to lysine-20 through a -Glu spacer plus two AEEA (8-amino-3,6-dioxaoctanoic acid) units supports reversible albumin binding, extending plasma half-life to approximately five days
Mutant FUS R495X dysregulates the expression of genes associated with oxidative mitochondrial metabolism in neurons, and significantly reduces the size of mitochondria, which induces neurotoxicity (Nakaya and Maragkakis, 2018)
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This is what makes the combination potentially more effective than either peptide alone
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