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The second concerns endpoints: a program built around biomarker movement needs a clear, pre-specified theory of how that biomarker connects to clinical benefit, and a plan for what a divergence would mean

Rates of kidney stones are on the rise in the United States and around the world

Im a big fan of Nooms philosophy that small steps can lead to big change, said Rebel Wilson

Rather than following traditional dosing protocols, patients and physicians are exploring whether smaller amounts can still provide meaningful benefits while minimizing potential side effects

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