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In vivo study demonstrated that topical application of OPs on the skin significantly alleviated moisture loss, epidermal hyperplasia, as well as degradation of collagen and elastin fibers caused by chronic UVB irradiation
Archives of Internal Medicine
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Description: IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic analog of human IGF-1, specifically modified by substituting arginine at position 3 and adding a 13-amino acid extension at the N-terminal
Sikiric et al., 2020b) without toxicity (lethal dose 1 (LD1) could be not obtained) (Sikiric et al., 1993
Nevertheless, various studies reported that an extensive pre-purification (Toll et al., 2006) or specific solid-phase extraction (Goumenou et al., 2025) yielded a mass spectrum of the intact subunit
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