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Its derivative, phenylbutyric acid, exhibits similar protective effects, including maintenance of antioxidant enzyme activity via inhibition of mitochondrial ROS accumulation and HO release, reduction of myocardial apoptosis through downregulation of iNOS/nitrotyrosine expression, and attenuation of collagen deposition by inhibiting the CTGF/MMP-2 pathway (Russo et al., 2019)
Additionally, there is no feasible way to overcome the side effects of oral administration of glutathione, since simply increasing the dose does not result in increased circulating blood levels and increases the frequency of unwanted side effects
Fortunately, dermatological intervention can typically control the symptoms of this potentially life-disruptive disorder
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doi: 10.3389/fpubh.2020.507024, 59 LiuJ.LuoM.ZhangY.CaoG.WangS
For maintenance, most patients receive one injection every 2 to 3 months
