The underlying science, that gut bacteria and SCFAs influence GLP-1, is real and well documented
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Biomed Pharmacother 2018;108:952-62.ArticlePubMed 14
According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications should be considered as an adjunct to lifestyle therapy in all patients with T2DM as needed for weight loss sufficient to improve glycemic control, lipids, and blood pressure
The 24% average at the highest dose exceeds tirzepatide, with some participants losing over 30% of body weight