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[] These factors can form a hyporesponsive inflammatory state by regulating the expression of pro-inflammatory factors and cytokines, affecting cell differentiation and apoptosis, interfering with the normal oxidative response of cells, and resulting in their toxic effects on cells

Centenarians have plasma MOTS-c levels resembling those of people decades younger, suggesting preserved mitochondrial signaling is a feature of exceptional aging

Abstract Glutathione (GSH), the most abundant intracellular low molecular weight thiol, has diverse physiological roles, and altered GSH status has been implicated in a number of chronic, acute, and age-related diseases, as well as the aging process itself

In a human trial, high-fiber diets improved sleep and even shifted chronotype earlier (toward morningness), potentially by these gut-mediated pathways (Tarta-Arsene et al., 2017

& Madre, R