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doi:10.1128/jb.01381-07
NNMT-related research is relevant to models involving adipocyte biology, NAD+-associated pathways, methylation-linked metabolism, and cellular energy regulation
The majority of research is preclinical (animal studies)
Reduced contractile activity lowers ATP turnover and disturbs mitochondrial respiratory flux, increasing electron leakage from complexes I and III of the electron transport chain and promoting mitochondrial superoxide and hydrogen peroxide generation
Metabolic effects of long-term reduction in free fatty acids with acipimox in obesity: A randomized trial
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