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Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction

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In response to an increase in the cytosolic Ca 2+ concentration, the Gardos channel opens, resulting in the efflux of K + with subsequent hyperpolarization driving Cl - exit (through Cl - channels)

Commonly reported side effects (incidence 5%) include: nausea, diarrhea, constipation, vomiting, injection site reactions, headache, low blood sugar, heartburn, fatigue (sleepiness), dizziness, stomach-area pain, increased lipase (a pancreatic enzyme), upper stomach-area pain, fever, and stomach infection (gastroenteritis)