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Nelson to break down metabolic flexibility , physiologic flexibility , and how building adaptability across multiple systems of the body creates a healthier, more responsive physique

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GLP-1 and GIP activation primarily work through appetite suppression and insulin modulation they don't significantly increase basal metabolic rate or activate brown adipose tissue in the same way glucagon does

These medications slow stomach emptying, which can increase the risk of aspiration during anesthesia

Studies on nasal mucosa absorption of small peptides consistently report bioavailability ranging from 15-40% of equivalent injected dose, depending on formulation

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