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In addition to the FDAs scrutiny of outsourcing facilities and compounders in the GLP-1 space, the FDA has expressed concerns over the use of unapproved GLP-1 drugs for weight loss, 2 including dosing concerns with compounded semaglutide and tirzepatide products, salt forms that should not be used to compound semaglutide, use of retatrutide in compounding, and adverse events related to compounded versions of semaglutide and tirzepatide, among others
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Dehydration can reduce kidney filtration efficiency, potentially slowing tirzepatide clearance, so maintaining adequate hydration supports optimal medication elimination
Prevalence of and factors associated with sarcopenia among multi-ethnic ambulatory older Asians with type 2 diabetes mellitus in a primary care setting
Novo is also taking legal action against compounders, telling Hunterbrook it has filed 63 lawsuits nationwide, across 19 states, against medical spas, weight-loss clinics and compounding pharmacies engaging in unlawful marketing and sales of compounded drugs claiming to contain semaglutide. 6 The company said it will continue to pursue legal recourse against other entities engaged in similar conduct. This raises the question: Given the uncertainty around the future of compounding for these drugs, will Hims transition away from compounding, or will it gamble on prolonging its high-margin business and risk legal blowback
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