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NNMT consumes S-adenosylmethionine (SAM) as a methyl donor, and inhibiting NNMT could theoretically increase SAM availability for other methylation reactions
Nat Commun 17 , 1800 (2026)
reduced glutathione, an important intracellular metabolite for regulation, is a prosthetic group of glyceraldehyde phosphate dehydrogenase, is a coenzyme of glyoxalase and triose dehydrogenase, participates in tricarboxylic acid cycle and sugar metabolism in vivo, and can activate various enzymes such as sulfhydryl (-SH) enzyme-coenzyme and the like, thereby promoting carbohydrate, fat and protein metabolism
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It is frequently utilized for research purposes by scientists and researchers
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