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If significant GI symptoms are present on the day of surgery (nausea, vomiting, bloating, abdominal pain, etc.), consider delaying the procedure
The 28-day window became standard practice because it provides a safety margin while maintaining potency assurance for patients
If you have diabetes and are taking it along with other medications, especially some of the older ones or insulin that are designed to lower blood sugar quickly, these will definitely add potency
Several FXR-activating medications are currently under clinical development, each with slightly different structures and pharmacodynamic effects (Figure 2)
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If I couldn't have afforded it, I would have been OK, but I don't regret it
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