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In particular, the suboptimal pharmacokinetics and pharmacodynamics of these compounds and their poor ability to cross the BBB could represent considerable obstacles for a significant therapeutic efficacy
10.1080/14737167.2017.1313118 Expert Rev
Complement Ther Med
The overall heterogeneity for total death was I 2 = 33.7% (95% uncertainty intervals, 0 and 60.9%) (moderate) (Additional file 1: Table S3)
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