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If you follow a vegan diet, youre at high risk of B12 deficiency because B12 is primarily found in animal products like meat, fish, eggs and dairy

Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance

Vitamin B12 is a co-factor in the transfer of methyl groups in the body, important in the synthesis of DNA

Common effects usually mild and often worst during titration include nausea, vomiting, diarrhea, constipation, abdominal pain, upset stomach, headache, and fatigue

Reported applications include NNMT enzyme inhibition assays measuring 1-methylnicotinamide formation or S-adenosylhomocysteine release, intracellular target-engagement assays in differentiated 3T3-L1 adipocytes where 5-Amino-1MQ reduced intracellular 1-methylnicotinamide with an EC near 2.3 M (Neelakantan et al., Biochem Pharmacol, 2018), membrane permeability and Caco-2 transport characterisation, methyltransferase selectivity panels covering COMT, DNMT1 and PRMT3, and rodent studies of NNMT inhibition in adipose tissue and liver following the antisense knockdown work of Kraus and colleagues (Nature, 2014)

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