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Updated June 2026 Author: Allison Jones, F-NP Medically reviewed by Dr

With the dosage increased, I noticed a big difference almost immediately

Semaglutide mimics GLP-1, a natural hormone in your intestines that plays a critical role in controlling blood sugar levels after you eat

Dose escalation is used because gastrointestinal side effects are common, especially early in treatment or after dose increases

When thyroid hormone replacement is optimized, meaning your TSH is within target range and you feel well, your metabolic rate returns to approximately normal

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